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Figure 10
Figure 10. Neighbour-joining tree, prepared by Nesher et al., (2013), demonstrating the evolutionary relationships between AdE-1 and typical sea anemone neurotoxins that target sodium channels. Type II neurotoxins are delineated in blue whilst type I is in magenta. The distances between neurotoxins are to scale and have been determined based on the number of amino acid substitutions per site to. Notably, AdE-1 exhibits no polar residues specifically N16 which has been conserved by all characterised sea anemone Na+ channel type 1 and type 2 toxins.
Figure 10